MEDICAL PROFESSIONALS

Autoimmune Encephalitis

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Hypothyroid

Hyperthyroid

Diabetes Type 1

Diabetes Type 2

Leukemia

Breast Cancer

Prostate Cancer

The GLOBAL Guidelines provides an evidence-based medical recommendations to support clinicians in their care of adults with Down syndrome.

Click here to download a copy of the GLOBAL Medical Care Guidelines for Adults with Down Syndrome.


The American Academy of Pediatrics (AAP) has developed a special guide to help parents and families of children with Down syndrome. This document focuses on medical topics that affect physical health.

Click here to download the complete guide, “Health Care Information for Families of Children with Down Syndrome” (PDF).

Genetic Testing

Mosaic Down syndrome

PANS/PANDAS

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Sensorineural Hearing Loss

Conductive Hearing Loss

Tonsils & Adenoids

Ear Infections

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DOWN SYNDROME MEDICAL CLINICS

WEBINARS & VIDEOS

BOOKS & PAMPHLETS

  • The Little King and His Marshmallow Kingdom – Louis Rotella III
  • We’ll Paint the Octopus Red – Stephanie Stuve-Bodeen

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  • Expecting Adam – Martha Beck
  • My Heart Can’t Even Believe It – Amy Silverman
  • Bloom – Kelly Hampton
  • Jewel – Brett Lott

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THERAPY PROFESSIONALS

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DEVELOPMENT & BEHAVIOR

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Clinical Trials for DS
  • Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults with Down Syndrome
    • Interventional | Active, Not Recruiting
      • Age: 25-45 years |Location: St. Joseph’s Hospital and Medical Center-Barrow Neurology Clinics, Phoenix, AZ
      • Trial Description:
        The purpose of this study is to test in adults with Down Syndrome the safety, tolerability and immunogenicity of a vaccine, ACI-24.

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  • Study of Alzheimers Disease in Down syndrome
    • Observational | Recruiting
      • Age: 25+ | Location: Barrow Neurological Institute, Phoenix, AZ 85013 
        Contact: Sandy Quintanilla | 602-406-7054 | sandy.quintanilla@dignityhealth.org
        Principal Investigator: Anna Burke, M.D.
      • Trial Description: This is an observational, multi-center, longitudinal cohort study to characterize adults with DS ages 25 years and above enrolled at specialized care centers. The aim is to assess changes in cognition, behavior, function and health over approximately 24 months. Blood will be collected for the development of plasma AD biomarkers useful in the Down syndrome population.

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  • SPARK:  sponsored by the Simons Foundation Autism Research Initiative, has the mission of speeding up research and advancing understanding of autism by building the nation’s largest autism study.
    • You can register online and contribute a saliva sample using a collection kit from your home.
    • Individuals with autism will receive gift cards valued up to a total of $50 for participating.
    • Registration and information can be found online at www.SPARKforAutism.org/BCH.
  • B-Lymphoblastic Leukemia
    • Study to investigate Blinatumomab in combination with Chemotherapy in Patients with newly Diagnosed B-Lymphoblastic Leukemia
    • Interventional | Recruiting
      • Age: 365 days to 31 years
      • Locations:
        Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ, Banner University Medical Center, Tucson, AZ
      • Trial Description:This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome.

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  • Acute Myeloid Leukemia
    • Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients with Down Syndrome
    • Interventional | Recruiting
      • Age: 91 days to 3 years
      • Locations: Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ
      • Trial Description:This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome.

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  • Risk-Adapted Chemotherapy
    • Risk-Adapted Chemotherapy in Treating younger patients with newly diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
    • Interventional | Active, Not Recruiting
      • Age: 1-30 years
      • Locations: Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ, Banner University Medical Center, Tucson, AZ
      • Trial Description: This partially randomized phase III trial studies the side effects of different combinations of risk-adapted chemotherapy regimens and how well they work in treating younger patients with newly diagnosed standard-risk acute lymphoblastic leukemia or B-lineage lymphoblastic lymphoma that is found only in the tissue or organ where it began (localized).

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  • Medications for Obstructive Sleep Apnea in Children with Down Syndrome
    • Interventional | Not yet recruiting
      • Age: 6-17 years | Location: University of Arizona | Tucson, AZ
      • Interventions: Drug – Atomoxetine and oxybutynin (ato-oxy)
      • Study DescriptionThis is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG).
  • Study of Blood Samples from Newborns with Down Syndrome
    • Observational | Active, Not Recruiting
      • Age: Up to 90 days
      • Location: Phoenix Children’s Hospital, Phoenix, AZ
      • Trial Description:  This research study is looking at blood samples from newborns with Down syndrome. Studying the genes expressed in samples of blood from patients with Down syndrome may help doctors identify biomarkers related to cancer.

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